Schematic diagram show the process of DBS. In DBS, STN or thalamus or the globus pallidus interna (Gpi) (in this case STN) are stimulated by an implanted apparatus contains batteries that produce electrical stimulation (like a pace-maker). Stimulating the STN can activate the GPi, which can strongly inhibit the thalamus (right side circuitry) which can activate the motor cortex; in turn, allowing more control into the movement of limbs
In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children. Wagner PJ, Park HR, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. Environ Health Perspect. 2017 Apr;125(4):721-729. doi: 10.1289/EHP265. Epub 2016 Aug 26.
Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders. Stansfield KH, Pilsner JR, Lu Q, Wright RO, Guilarte TR. Toxicol Sci. 2012 May;127(1):277-95. doi: 10.1093/toxsci/kfs090. Epub 2012 Feb 17.
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