Ceftriaxone injection is a powerful antibiotic, but certain individuals should avoid it. People allergic to ceftriaxone injection or other cephalosporin antibiotics should not use it. Newborns with jaundice or those receiving calcium-containing IV solutions should also avoid ceftriaxone injection due to the risk of fatal reactions. Patients with severe kidney or liver disease should use ceftriaxone injection cautiously, as it may require dose adjustments. Individuals with a history of gallbladder disease or colitis should consult a doctor before using ceftriaxone injection. Always inform your healthcare provider of any medical conditions before receiving ceftriaxone injection to ensure safe use.